Do Glucosamine Supplements Work for Arthritis?

Do Glucosamine Supplements Work for Arthritis?


Glucosamine is a well-liked dietary complement used to deal with osteoarthritis.

Osteoarthritis is a degenerative illness attributable to inadequate regeneration of cartilage in joints, most frequently within the knees and hips.

It will get worse over time and causes joint ache, difficulties strolling and incapacity.

There isn’t any recognized remedy, however there are a couple of methods to doubtlessly sluggish the method. Many individuals attempt to stave off osteoarthritis by taking glucosamine dietary supplements.

However do they actually work? This text takes a have a look at the proof.

Glucosamine is a pure amino sugar produced by your physique. It’s also a dietary complement marketed as a substitute remedy for osteoarthritis.

The best pure focus of glucosamine is in joints and cartilage the place it makes up the construction of glycosaminoglycans, compounds important for joint well being (1).

Dietary supplements are usually processed from crustacean shells or produced by the bacterial fermentation of grains (2).

They’re broadly out there and offered within the type of tablets, capsules, delicate gels or drink mixes. There are two important sorts: glucosamine sulfate and glucosamine hydrochloride.

The way in which glucosamine impacts arthritis is unclear. Scientists imagine naturally occurring glucosamine helps shield the cartilage inside your joints (3).

Moreover, a number of research recommend that taking glucosamine dietary supplements could cut back collagen breakdown (4, 5).

The dietary supplements may additionally work by reducing inflammation, which is without doubt one of the important causes of joint cartilage breakdown in osteoarthritis sufferers (6).

Nevertheless, the effectiveness of those dietary supplements is debated.

Abstract: Glucosamine is a dietary complement usually used to deal with osteoarthritis. Scientists aren’t fully positive the way it works, however research recommend it could cut back cartilage breakdown.

Glucosamine is without doubt one of the world’s hottest dietary supplements. It’s additionally among the many most controversial.

Right here is the analysis about the way it impacts the 2 frequent kinds of arthritis.


Whereas many research conclude that glucosamine has no advantages for osteoarthritis, others point out that it could relieve joint ache and different signs over time.

This particularly applies to glucosamine sulfate salts, a formulation patented by the pharmaceutical firm Rottapharm.

One managed research in 318 adults with osteoarthritis discovered that taking 1,500 mg of the “Rotta formulation” every day for half a 12 months diminished ache and improved perform greater than a placebo.

The advantages appeared just like a every day three g dose of acetaminophen — a generally used ache reliever (7).

One other two research, which included round 200 individuals, confirmed that taking 1,500 mg of glucosamine sulfate every day for 3 years improved their total signs — together with ache, stiffness and performance — in comparison with a placebo (8, 9).

Nevertheless, these research have been probably industry-influenced since Rottapharm financed all three. At present, no massive, long-term, industry-independent research on the effectiveness of glucosamine can be found.

An unbiased evaluation of a number of high-quality research concluded that the “Rotta formulation” improved sure measures of ache and performance greater than a placebo, whereas different types didn’t present any important advantages (10).

That stated, the advantages of taking glucosamine sulfate are small and a few researchers contemplate them clinically irrelevant (11).

Abstract: The advantages of this complement are controversial. Some research recommend that glucosamine sulfate could barely enhance osteoarthritis signs when taken for at the very least half a 12 months.

Rheumatoid Arthritis

Osteoarthritis shouldn’t be confused with rheumatoid arthritis, which is way much less frequent.

Rheumatoid arthritis is an autoimmune illness during which the immune system assaults the joints. In contrast to osteoarthritis, it’s not attributable to on a regular basis put on and tear.

Scientists have typically assumed that glucosamine has no advantages for rheumatoid arthritis.

However, one research in 51 adults with rheumatoid arthritis suggests in any other case. It discovered that taking 1,500 mg of glucosamine hydrochloride for 3 months improved self-assessed signs greater than a placebo (12).

Nevertheless, extra research want to substantiate these findings earlier than any strong conclusions could be made.

Abstract: Restricted proof signifies that glucosamine hydrochloride could enhance signs in individuals with rheumatoid arthritis. Nevertheless, extra research are wanted.

These dietary supplements are broadly out there and straightforward to search out.

Glucosamine sulfate seems to be more practical than glucosamine hydrochloride, so when you resolve to attempt these dietary supplements, your finest guess is the sulfate kind (13, 14).

One other issue to contemplate is the standard of the product you’re shopping for. One research discovered that the quantity of glucosamine in dietary supplements was usually decrease than reported (15).

Glucosamine high quality is carefully monitored in most European international locations the place it’s marketed as a pharmaceutical. In North America, it’s categorized as a nutraceutical, and its manufacturing and advertising and marketing might not be as strictly managed.

If you’re shopping for American dietary supplements, select those who have a high quality certification from a third-party company. These embody Informed Choice, NSF International and the US Pharmacopeial Convention (USP).

Moreover, glucosamine is usually offered together with chondroitin sulfate, a complement additionally used to scale back the signs of osteoarthritis.

Its effectiveness is debated, however some research recommend it could cut back ache when used alone or together with glucosamine (16).

Abstract: If you happen to resolve to complement with glucosamine, select merchandise that comprise the sulfate kind and have a high quality certification.

Typically, glucosamine must be taken with meals thrice per day.

Doses normally vary from 300–500 mg with every meal, including as much as a complete every day dose of 900–1,500 mg. Most research used 1,500 mg per day.

Salts of glucosamine sulfate or the “Rotta formulation” solely should be taken as soon as per day. Make certain to comply with the directions on the packaging.

These dietary supplements are thought of protected and no severe negative effects have been reported. Flatulence is the commonest grievance.

Research additionally point out that glucosamine injections could worsen insulin sensitivity, however dietary supplements don’t appear to have the identical impact (17).

Abstract: Glucosamine dietary supplements are thought of protected and haven’t any severe negative effects. The usual dosage is 1,500 mg per day.

Glucosamine is a controversial complement.

Many research haven’t detected any important advantages, whereas others recommend the sulfate kind could cut back the signs of osteoarthritis and delay or sluggish its improvement.

However, some scientists nonetheless doubt the effectiveness of glucosamine or contemplate its small advantages clinically irrelevant.

Whereas glucosamine is not any magic resolution, others level out that dietary supplements can not harm and could also be higher than no remedy in any respect.


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